Filed under: Dietary supplements
Synthetic drugs are laboratory-made substances marketed and sold as alternatives to illegal drugs such as marijuana, cocaine, and amphetamines. Although most are advertised as “all-natural,” they may have serious health effects and violate the Uniform Code of Military Justice (UCMJ). HPRC takes a look at two examples of synthetic drugs, their legal status, and how they can affect service members in “HPRC’s Answer: Synthetic Drugs of Abuse.”
Carnitine is a naturally occurring substance in the human body that helps cells use fat for energy. The liver and kidneys can produce carnitine from amino acids provided by the diet, but carnitine also comes from many foods, especially red meat, and is an ingredient in many dietary supplements and energy drinks.
Sometimes doctors use carnitine to treat certain heart conditions. Recent clinical trials suggest that carnitine supplements may help reduce many of the complications associated with heart attacks, such as chest pain and irregular heart rhythms.
But new research suggests that long-term consumption of dietary carnitine also may play a role in the development of atherosclerosis—“hardening of the arteries”—especially in people who eat red meat regularly. So what’s the bottom line? More research is needed to determine the risks and benefits associated with carnitine.
You can learn more about carnitine in HPRC’s Dietary Supplement Classification System.
The Food and Drug Administration (FDA) has issued a Consumer Update warning of the potential dangers of DMAA, which was announced illegal in dietary supplements on 11 April 2013. DMAA is also referred to as dimethylamylamine and other names. This dietary supplement product ingredient has been used in many weight-loss, bodybuilding, and performance-enhancement products. FDA received numerous reports of illnesses and death from the use of products containing DMAA; commonly reported reactions include heart and nervous system problems as well as psychiatric disorders. DMAA has been the focus of conflicting information regarding whether or not it is a natural extract from geranium. FDA has now found “the information insufficient to defend the use of DMAA as an ingredient in dietary supplements.” Online, FDA also stated, "Dietary supplements containing DMAA are illegal and FDA is doing everything within its authority to remove these products from the market."
For more information, read the FDA Q&A on DMAA here.
The Food and Drug Administration (FDA) has issued a Consumer Update warning of the potential dangers of DMAA, which was announced illegal on 12 April 2013. DMAA is also referred to as dimethylamylamine and other names. This dietary supplement product ingredient has been used in many weight-loss, bodybuilding, and performance-enhancement products. FDA received numerous reports of illnesses and death from the use of products containing DMAA; commonly reported reactions include heart and nervous system problems as well as psychiatric disorders. DMAA has been the focus of conflicting information regarding whether or not it is a natural extract from geranium. FDA has now found “the information insufficient to defend the use of DMAA as an ingredient in dietary supplements.” Online, FDA also stated, "Dietary supplements containing DMAA are illegal and FDA is doing everything within its authority to remove these products from the market."
For more information, read the FDA Q&A on DMAA here.
Energy drinks have been in the news lately, mostly due to media reporting on a group (doctors, researchers, scientists, and politicians) writing to the Food and Drug Administration (FDA) to express concern over the use of these drinks by adolescents. Much of the concern has to do with the amounts of caffeine in these drinks, among other issues. Energy drinks also may contain large amounts of other stimulants, including guarana, yohimbe, yerba mate, kola nut, methylsynephrine, Citrus aurantium (Bitter Orange), and Ma Huang (ephedra). Although listing the total amount of caffeine on the label would help, consumers should be aware that there are often other stimulants in energy drinks.
The American Academy of Pediatrics has written several articles over the last year about the potential risks associated with the adolescent population using energy drinks. One very recent article outlines the harmful effects of energy drinks on adolescents, including increased heart rate, high blood pressure, anxiety, digestive problems, sleep disturbances, and dehydration. The withdrawal effects after habitually consuming energy drinks is also an issue, as it can lead to headaches and attention problems. Also, the ingestion of energy drinks by adolescents who take prescription drugs for Attention Deficit Hyperactivity Disorder (ADHD) or who have eating disorders or diabetes is another topic of concern.
The amount of caffeine contained in energy drinks is not regulated, as the FDA does not regulate caffeine in foods or beverages, except that the maximum concentration for caffeine in cola beverages is 71 mg per 12 oz. The amount of caffeine in energy drinks ranges from 50 to more than 500 mg per can or bottle. The American Academy of Pediatrics recommends that children and teens drink no more than 100 mg of caffeine per day. To put that in perspective, an eight-ounce cup of coffee typically contains about 100 mg of caffeine (or more), and the most popular caffeine-containing sodas contain around 30 to 55 mg in a 12 oz. can. Not knowing how much caffeine and other stimulants are contained in energy drinks is a potential health threat.
Furthermore, the caffeine and other stimulants contained in the energy drinks, when combined with alcohol, can mask the symptoms of alcohol intoxication, potentially leading to risky behavior. The American Academy of Pediatrics advises parents and doctors to talk to children about the dangers of mixing alcohol and energy drinks, and the Centers for Disease Control and Prevention has a fact sheet on the potential risks.
Parents, educators, and healthcare professionals need to focus on educating adolescents about potential problems associated with consuming these high-stimulant products. Companies are heavily marketing their products by featuring athletic superstars, which causes children and adolescents to confuse energy drinks with sports drinks. Generally speaking, adolescents don’t need energy drinks, and they should be made aware of the potential dangers. It’s definitely a case of “buyer beware.”
Visit HPRC’s Operation Supplement Safety (OPSS) to access resources on the informed use of dietary supplements.
Raspberry ketone, touted to be an effective fat-loss and weight-loss supplement, occurs naturally in various red raspberries. The raspberry ketone in supplements is probably produced in the laboratory, as it would be too expensive to extract it from real raspberries. FDA recognizes that raspberry ketone as a food additive is “Generally Recognized as Safe” (GRAS) to consume in small amounts. However, the long-term effects in humans who consume it as a supplement are unknown. For more information, read HPRC’s InfoReveal on “Raspberry ketone.”
Be extra cautious when taking dietary supplements before and after surgical procedures; some products can have serious negative effects on surgical procedures. For instance, certain supplements prevent certain blood cells (platelets) from clumping, resulting in excessive bleeding during surgery. Some of the ingredients commonly found in supplements that hinder platelet aggregation are ginko biloba, saw palmetto, glucosamine, black tea, fish oil, and garlic. If you are having a surgical operation, consider abstaining from these items or consume these items in moderation a few weeks before and after the procedure. For more a complete list of products and additional information, including other surgical risks associated with dietary supplements, read this web page from the Natural Medicines Comprehensive Database. And always read product labels carefully; many include warnings of potential medical risks, including the length of time prior to surgery that you should discontinue use.
Both deer velvet and IGF-1 have been in the news lately, and HPRC has received many questions about what these are and whether they improve athletic performance. Does deer velvet contain IGF-1? Read this OPSS FAQ about deer velvet to find out. To learn what IGF-1 is and whether it is banned in the military, read more in the OPSS FAQ about IGF-1. Be sure to check back often, as we add answers to other questions about ingredients in performance and weight-loss supplements and how to choose supplements safely.
It can be tough figuring out the truth about the health benefits of many natural products. One product that’s getting a lot of attention these days is green coffee beans. As a Warfighter looking for ways to optimize your performance or perhaps drop some weight quickly, it’s easy to be overwhelmed by all the marketing hype and claims, especially if it’s an appealing message. Make sure you get the facts.
Green coffee beans are the raw, unroasted seeds or “beans” of the Coffea plant. They contain a chemical called chlorogenic acid (CA) that supposedly offers some health benefits. Roasting reduces the amount of CA in coffee beans; as a result, green coffee beans contain more CA than the roasted beans you use for your morning coffee. Some research suggests that CA might prevent heart disease, diabetes, and high blood pressure, and help with weight loss. But it’s important to note that most of this research is preliminary, and there just isn’t enough evidence to say that CA will definitely help with any of these health conditions.
Although no serious side effects have been reported from green coffee beans in their natural form, some dietary supplement products containing green coffee beans have been found to contain undeclared drugs, insects, and mold. Of the 126 products containing green coffee beans ranked by the Natural Medicines Comprehensive Database, 40 have been assigned a rating of “1” or “2,” which indicates there are serious concerns about their safety and effectiveness. None have a rating in NMCD’s green zone, which suggests that there are some concerns about them all. Note also that green coffee beans are not always the only active ingredient, so be sure to check the product label.
It’s also important to note that green coffee beans contain caffeine. Side effects of consuming too much caffeine are all too familiar—difficulty sleeping, rapid or irregular heartbeat, nervousness, nausea, and vomiting. Pregnant and breastfeeding women, or those who have been diagnosed with certain medical conditions (including anxiety, diabetes, irritable bowel syndrome, high blood pressure, or osteoporosis) should check with their doctor before consuming green coffee beans. For more information on caffeine, read the OPSS FAQ on caffeine.
HPRC has received many questions about C4 Extreme and whether or not it will result in a positive drug test. We have posted an OPSS FAQ to answer the question. Be sure to check back often as we add answers to other questions about ingredients in performance and weight-loss supplements and how to choose supplements safely. If you have additional questions about a particular dietary supplement ingredient or product, please use our “Ask the Expert” button located on the OPSS home page.