You are here: Home / HPRC Blog

Filed under: Dietary supplements

FDA says no to methylsynephrine

FDA has declared that methylsynephrine can’t be used in dietary supplements. Be sure to check your product label.

The Food and Drug Administration recently announced that methylsynephrine (also known as oxilofrine) “does not meet the statutory definition of a dietary supplement ingredient.” So what does this mean? Products containing methylsynephrine are adulterated and can’t be marketed legally as dietary supplements. Methylsynephrine is also prohibited in sport because it’s a pharmaceutical drug (not currently approved in the U.S) and a stimulant that increases blood pressure and affects heart rate. What’s more, some supplements have been found to contain methylsynephrine in amounts equal to or greater than pharmaceutical doses.

The consequences of taking methylsynephrine in large amounts or in combination with other stimulants aren’t entirely known, but one product containing this ingredient and other stimulants has been linked to nausea, vomiting, agitation, increased heart rate, chest pain, and cardiac arrest. If you’re considering taking a dietary supplement with methylsynephrine or oxilofrine on the label, you might want to think twice. For more from FDA, please see “Methylsynephrine in Dietary Supplements.”

SARMs don’t cut it

SARMs are unapproved drugs that keep popping up in dietary supplement products.

SARMs (selective androgen receptor modulators) are unapproved, experimental drugs sometimes illegally marketed and sold as dietary supplement products. They’re also available on the Internet in other forms, but their use in sport is prohibited. Use of SARMs can affect military performance and readiness.

Operation Supplement Safety (OPSS) has an FAQ about SARMS, including a link to a list of more than 200 dietary supplements and other commercial products containing SARMs. The list also includes an extensive list of SARM names to help you identify them on product labels.

HPRC’s Ask the Expert feature is available if you have particular questions about these ingredients or any other questions about dietary supplements.

Nootropics on your mind?

If you’re looking for cognitive enhancers or “smart drugs,” you may want to think twice.

Many dietary supplement products are marketed as nootropics—substances intended to improve memory, focus, and overall mental performance. While some products contain vitamins, minerals, and plant-based ingredients, others contain drugs that are not legal dietary supplement ingredients. Read the Operation Supplement Safety (OPSS) FAQ about nootropics to learn more about these products and whether they are safe and effective.

Not all ingredients found in dietary supplements are legal, so read product labels carefully. For more information, visit FDA’s Dietary Supplement Products & Ingredients.

Put aside the pills and powders

Think you need that dietary supplement? Think again. National Nutrition Month reminds us to choose real foods first.

March is National Nutrition Month, a good reminder to eat healthfully and choose the best foods to fuel our bodies. This year’s theme is “Savor the Flavor of Eating Right,” which isn’t something we can often say about dietary supplements that come in the forms of pills and powders. If you’re looking for a supplement to lose weight, build muscle, or enhance your performance, HPRC always recommends choosing nutrient-rich foods first. They taste better and are better for you. Use the Operation Supplement Safety (OPSS) “Real Food” poster to see what foods can help you meet your goals.

If you’re still considering dietary supplements, be sure to visit OPSS where you’ll find answers to frequently asked questions, infosheets, videos, and other educational materials to help you make an informed decision. And remember to always talk to your doctor before taking any supplement.

What’s a “new dietary ingredient”?

Some dietary supplements can contain at least one “new dietary ingredient.” If you haven’t heard this term before, you’re not alone.

If a dietary supplement product contains something called a “new dietary ingredient,” manufacturers or distributors must notify the Food and Drug Administration (FDA) before marketing any product that contains the ingredient. Aside from this, FDA doesn’t review or approve dietary supplements before they’re marketed. So what’s a “new dietary ingredient,” what makes it different from other ingredients, and what has to be done before one can be used in dietary supplements? Find out in the OPSS FAQ about new dietary ingredients.

Do you have more questions about other dietary supplement terms, regulations, or policies? Check out the other OPSS FAQs for some answers. If you can’t find what you’re looking for, send us a question using our Ask the Expert feature.

Chia seeds and drug testing

Will chia seeds cause a positive drug test? Read more and find out what you really need to avoid.

Chia (Salvia hispanica) seeds are rich in omega-3 fatty acids and fiber. As such, they have become a popular food item, and you can also find chia (seeds and oil) in many dietary supplements marketed to support heart and digestive health. On its own, chia will not produce a positive drug test. However, when you look at ingredient lists on product labels, don’t confuse Salvia hispanica (chia) with Salvia divinorum (Diviner’s sage), which is banned by some services. There are many types of salvia, so please read the OPSS FAQ about salvia for more information. If you’re interested in learning more about chia seeds, visit this webpage from MedlinePlus.

Will Phentermine cause a positive drug test result?

Read the OPSS FAQ to find out if phentermine will cause a positive drug test result.

HPRC has received a lot of questions about phentermine, a prescription drug used for weight loss that’s similar to amphetamine. If you’re a service member, is it okay to use as long as you have a prescription? Will you pop positive on your drug test? Read the OPSS FAQ to find out answers to these questions.

For answers to other frequently asked questions that we’ve received, visit the FAQs section of OPSS. You can also visit the OPSS High-Risk Supplement List for information about certain dietary supplements that may pose a sport anti-doping or health risk.

Wondering about weight-loss supplements?

Ask yourself just three questions before you take a weight-loss supplement.

Trying to lose weight as your New Year’s resolution, meet body composition standards, or just be healthier? Weight-loss supplements might be a tempting solution, but before you take one, ask yourself these questions:

  • Is it safe? Having a faster heart rate isn’t “normal” or a “good sign” that the supplement is working! Many weight-loss supplements contain plant-based ingredients and other stimulants that can have serious side effects such as chest pain, high blood pressure, and even heart attack. If you want to know about the safety of a specific product or ingredient, you can look it up in the Natural Medicines Comprehensive Database.
  • Does it work? Unfortunately, just because a product seemed to work for your friend doesn’t mean it’ll work for you. There’s limited scientific evidence that weight-loss supplements alone help people lose a significant amount of weight and keep it off. Question the claims on the label, and remember, if it sounds too good to be true, it probably is.
  • Do you know what’s in it? Many dietary supplement products marketed for weight loss have been found to contain hidden prescription drugs or compounds that haven’t been adequately studied in humans. Be sure to check the label to see if the product has been evaluated by an independent third-party organization.

If your goal is to lose weight this year, challenge yourself to do it the old-fashioned way with a healthy eating plan and regular physical activity. And be patient: Making changes to your lifestyle and body takes time, but you will see results.

For more information about weight-loss supplements, visit the Operation Supplement Safety (OPSS) FAQs about Weight Loss.

Stimulants in your supplement?

Do you know how to spot a stimulant and whether it’s a problem?

Stimulants are common (and potentially problematic) ingredients in dietary supplements such as pre-workout and weight-loss products. But do you know how to tell if your dietary supplement product actually contains a stimulant? OPSS has some answers. Check out the OPSS FAQs about why stimulants are a problem and how to identify them on labels, both of which link to our list of “Stimulants found in dietary supplements.”

And while you’re there, visit our other OPSS FAQs, where you’ll find information about specific stimulant ingredients such as DMAA, DMBA, BMPEA, yohimbe, and synephrine. We also have several FAQs about caffeine, probably the most common stimulant.

Is 5-HTP the key?

Can 5-HTP help with depression, appetite, and other conditions?

Your body makes 5-HTP, but it can also be made in a lab and used in dietary supplements. Products containing 5-HTP are marketed to help with a number of health conditions, including appetite control and depression. Do they work? Read the Operation Supplement Safety (OPSS) FAQ on 5-HTP to find out.

Do you have other questions about dietary supplements that need answers? Then check out our other OPSS FAQs, where you’ll find information about performance products, weight-loss products, specific ingredients, and more. 

RSS Feed